Diffuse hemangiomatosis of the liver is a rare condition of infancy characterized by extensive hemangiomas in the liver. It is extremely rare in adults. The imaging findings are similar to hemangioma showing centripetal enhancement with stasis of contrast. We present a case of hemangiomatosis of the liver and spleen in a 52 year old male patient. Following splenectomy there was enhanced growth of the hepatic hemangiomatosis within a period of four months and died soon after due to liver failure. We could not find a similar rapid progression of hepatic hemangiomatosis in our literature search.