A Case of ACTH Secreting Large Cell Neuroendocrine Carcinoma (LCNEC) of Bronchus

Oncology, Gastroenterology and Hepatology Reports,2012,1,1,47-53.
Published:July 2012
Type:Case Report
Author(s) affiliations:

Appalanaidu Sasapu, M D,1 Theepha Thayalakulasingam, M D,1 Arthur Zieske, M D,2 David Smith, M D,3 Fred Lopez, M D,1 and Brian Boulmay, M D1

1Department of Internal Medicine

2Department of Pathology

3Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, LA


Bronchopulmonary neuroendocrine tumors account for only 20% of all lung carcinomas. These tumors are separated into four subtypes of low-grade (typical carcinoids), intermediate-grade (atypical carcinoids) and high-grade carcinomas which include large cell neuroendocrine carcinoma (LCNEC) and small-cell lung carcinoma (SCLC). LCNEC is a rare entity of aggressive cancer with poor prognosis. LCNEC is typically seen in older male with significant smoking history. We are presenting a young man with only five pack year smoking history and cushingoid features who was found to have LCNEC.