Association of microbes in different cancers’ initiation and progression is very old and is still considered as an emerging field in cancer biology. Knowledge about the functional link between different microbes and cancer has enabled us in taking preventive measures against different cancers like gastric and cervical cancer. In the recent past, various clinical and experimental studies have shown presence of certain specific microorganisms in different cancer tissues that were not addressed before. Importantly, availability of certain animal models have helped in establishing the functional association between microbes and cancers. In this particular review, we have briefly summarized the role of commonly known microbes in various cancers and importantly discussed about the recent contribution of metagenomics analysis in this particular field.